Reprogramming the genetic code in vitro
نویسندگان
چکیده
منابع مشابه
Reprogramming the genetic code.
When Maria Leptin called to say that I had been awarded the 2010 EMBO Gold Medal, I was delighted and surprised. The roll call of past winners is impressive, and I had been at the Laboratory of Molecular Biology (LMB) when Jan Löwe had received the award in 2007 for his elegant work on the bacterial cytoskeleton (Michie and Löwe, 2006). I also knew that several other LMB scientists, including B...
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The genetic code of cells is near-universally triplet, and since many ribosomal mutations are lethal, changing the cellular ribosome to read nontriplet codes is challenging. Herein we review work on the incorporation of unnatural amino acids into proteins in response to quadruplet codons, and the creation of an orthogonal translation system in the cell that uses an evolved orthogonal ribosome t...
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C ells keep a record of their developmental history by chemically modifying their histones and DNA to alter chromatin structure and control gene expression. Resetting these epigenetic marks is an essential step in reprogramming adult cells to produce embryonic stem (ES)–like cells able to develop into every tissue of the body. Alex Meissner fi rst became interested in epigenetics as a graduate ...
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in current study, 63 samples of bat populations collected from differ regions were used for evaluating the geographic variations. twenty cranial and dental characters for traditional morphometric and landmarks method on the ventral, dorsal skull and mandible for geometry morphometric studies were used. statistical analyses of traditional morphometric and geometry morphometric data indicated low...
the effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2014
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2014.07.005